{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Sheet1","Sheet2","Sheet3"],"not_rendered":{"external_links":1,"defined_names":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":52,"n_cols":34,"rows_kept":52,"merged":[[0,0,0,33]],"flags":["formulas_cached_only"]}
["2023年度河北医学科技奖申报目录公示表"]
["序号"," 项目名称","申报奖种及等级","主要完成单位及排序","全部完成人及排序\n（前五）","项目创新点","论文1\n名称","全部国内作者","发表刊物（出版社）","发表（出版）时间（年 月 日）","论文2\n名称","全部国内作者","发表刊物（出版社）","发表（出版）时间（年 月 日）","论文3\n名称","全部国内作者","发表刊物（出版社）","发表（出版）时间（年 月 日）","论文4\n名称","全部国内作者","发表刊物（出版社）","发表（出版）时间（年 月 日）","论文5\n名称","全部国内作者","发表刊物（出版社）","发表（出版）时间（年 月 日）","论文6\n名称","全部国内作者","发表刊物（出版社）","发表（出版）时间（年 月 日）","论文7\n名称","全部国内作者","发表刊物（出版社）","发表（出版）时间（年 月 日）"]
[1,"MR扩散加权成像联合血清检测对原发性肝癌诊断价值","2023年度河北医学科技奖二等奖","1沧州市中心医院2任丘市第二人民医院3沧州和平医院","1.袁俊建2.许艳东3.李恒4.郭庆金5.李国策","应用MR扩散加权成像联合血清检测提高原发性肝癌诊断","MR扩散加权成像联合血清IP-10、GPC3检测在原发性肝癌诊断中的临床价值","李恒 袁俊建 许艳东 郭庆金 李国策","中国CT和MRI杂志","2023-07-01","Magnetic resonance imaging and serum AFP-L3 and GP-73 in the diagnosis of primary liver cancer","袁俊建 许艳东 李恒 郭庆金 李国策","Journal of Oncology","2022-04-01"]
[2,"慢性肾功能衰竭尿毒症期患者血管钙化危险因素筛查，诊断及同骨质疏松相关性研究","2023年度河北医学科技奖一等奖","沧州市中心医院 1","1.马晓迎  2.生玉平  3.王娜     4.张浩然   5.徐海平","发现25-羟维生素D水平变化可能为参与尿毒症期患者血管钙化及骨质疏松的共同机制之一。miR-29a-5p同慢性肾脏病患者血管钙化相关，且其同miR-129、硬化蛋白及胎球蛋白A均同慢性肾脏病血管钙化密切相关。","Expression profiles of miR-129 and miR-29a-5p in vascular calcificati -on of patients with end-stage renal disease and the underlying correlation","生玉平\n马晓迎\n王娜\n杨星梦\n张浩然\n徐海平\n孙福云","Cellular and Molecular Biology","2022-07-31","Expression of miR-129\n5p,sclerostin and fe\nTuin-A in patients with chronic kidney disease and their correlation with vascular calcifica\ntion","马晓迎\n生玉平\n杨星梦\n王娜\n张浩然\n徐海平\n孙福云","Cellular and Molecular Biology","2022-07-31","Characteristics and prognostic outcome \n\n\nFactors between young and elderly peritonea\nl dialysis patients:\na prospective cohort\nstudy","马晓迎\n生玉平\n杨星梦\n王娜\n张浩然\n徐海平\n孙福云","Annals of Palliative \nMedicine","2022-09-15","Idiopathic membranou\ns nephropathy in a patient diagnosed with IgG4-related disease:A case report","马晓迎\n徐海平\n孙景毅\nYuresha Surangani Siyabalagaba\nGedara\n孙福云","Medicine","2020-09-21","终末期肾病患者腹主动脉钙化和心脏瓣膜钙化的临床特点及危险因素的差异分析","马晓迎\n生玉平\n杨星梦\n王娜\n张浩然\n徐海平\n孙福云","中国血液净化","2021-07-12","透析患者25-羟维生素D水平与血管钙化的相关性研究","生玉平\n马晓迎\n杨星梦\n张浩然\n王娜\n徐海平\n孙福云","中国血液净化","2022-09-12","碳酸镧联合左卡尼汀治疗维持性血液透析慢性\n肾功能衰竭的临床研究","生玉平\n马晓迎\n杨星梦\n王娜\n张浩然\n徐海平\n孙福云","现代药物与临床","2022-07-21"]
[3,"沧州地区儿童维生素A、D、E水平与呼吸道感染的分析","2023年度河北医学科技奖一等奖","沧州市中心医院 1","1.张静2.孙蓉蓉3.伊文霞4.田文秋5.孙美","预期结果填补了本地区相关性研究的空白；为预防及治疗相关疾病提供重要依据；可有效节省卫生资源，对基层医院诊断治疗疾病亦有一定指导价值。","Correlation of serum vitaminA,D,andE with recurrent respiratory infection in children","张静，孙蓉蓉，阎志新，伊文霞，岳彬","European Review for Medical and Pharmacological Sciences",2019.09,"Clinical Monitoring of Serum Levels of Vitamins A,D and E in Children with Recurrent Respiratory Tract Infections of Different Ages:A Clinical Controlled Trial","孙蓉蓉，阎志新，伊文霞，田文秋，孙美，张静","International Journal of General Medicine","2022-08-17","宣肺补脾法结合维生素AD滴丸对小儿反复呼吸道感染的治疗效果及对免疫力的影响研究","伊文霞，张静，孙蓉蓉，田文秋，孙美，阎志新","《中华中医药学刊》","2020-11-09","The correlation between the vitamin A,D,andE levels and recurrent respiratory tract infections in children of different ages","田文秋，伊文霞，张静，孙美，孙蓉蓉","Am J Transl Res","2021 年5月15日","Dynamic monitoring and a clinical correlation analysis of the serum vitamin A,D,and E levels in children with recurrent respiratory tract infections","孙美，阎志新，孙蓉蓉，田文秋，伊文霞，张静","Am J Transl Res","2022-05-15"]
[4,"二甲双胍控制氧化代谢调节\nCyclin D延缓糖尿病合并肾细胞癌进展\n","2023年度河北医学科技奖二等奖","沧州市中心医院1","1.刘洋2.\n孟玲玲3.李建伟4.宋苗苗5.戚桂松","本课题积极探索二甲双胍的抗肿瘤机制，一方面可以了解二甲双胍延缓糖尿病合并肾细胞癌进展的机理，另一方面还可以分析二甲双胍治疗肾癌合并糖尿病患者的生存质量，将给临床上治疗糖尿病合并肾细胞癌提供新的思路。","High-Concentration Metformin Reduces Oxidative Stress Injury and Inhibits the Growth and Migration of Clear Cell Renal Cell Carcinoma","刘洋；孟玲玲；李建伟；宋苗苗；戚桂松","Computational And Mathematical Methods in Medicine","2022-05-01","Correlation analysis of alcohol consumption, smoking, duration of diabetes mellitus and postoperative recurrence and metastasis of renal cancer patients with type 2 diabetes mellitus","刘洋；孟玲玲；李建伟；宋苗苗；戚桂松","Indian J Pharm Sci","2023-04-01","Preliminary construction of prognostic risk early warning model for renal cell carcinoma patients with type 2 diabetes mellitus based on SMOTE algorithm","刘洋；孟玲玲；李建伟；宋苗苗；戚桂松","Indian J Pharm Sci","2023-05-01"]
[5,"重组人脑利钠肽序贯心脉隆对AMI后心衰心率变异性的研究\n","2023年度河北医学科技奖二等奖","沧州市中心医院 1","1.姚丽2.刘晨杰3.林瑜4.张力5.胡亚民","本研究将固定剂量（0.5μg/min）的重组人脑利钠肽与心脉隆注射液进行序贯治疗，观察其对急性前壁心肌梗死后急性心力衰竭患者心功能及心率变异性的影像，显示此序贯治疗方案可显著降低 N 末端脑钠肽前体（NT-proBNP）、提升左室射血分数（LVEF），改善心功能；同时此序贯治疗方案可显著提升心率变异性包括 SDNN、SDANN、RMSSD、PNN50 指标。在国内文献中未见相同报道。","固定剂量重组人脑利钠肽序贯心脉隆治疗急性前壁STEMI后心力衰竭患者的效果观察","姚丽，张力，刘晨杰，林瑜，胡亚民","中国中西医结合急救杂志","2021-08-28","Effect of metoprolol tartrate tablets and recombinant human B-type natriuretic peptide on the sudden cardiac death and malignant arrhythmias in patients with acute myocardial infarction and heart failure","刘晨杰，姚丽，张力，林瑜","Pakistan Journal of Pharmaceutical Sciences","2021-11-26","Influence of recombinant human B-type natriuretic peptide on improving ventricular function in patients with ST elevation myocardial infarction","姚丽,刘晨杰,张力，林瑜,胡亚民","European Review for Medical and Pharmacological Sciences","2023-04-28"]
[6,"BCAR4在神经胶质瘤中的表达及其意义","2023年度河北医学科技奖一等奖","沧州市中心医院 1","1.王志峰2.王龙龙3.李国京4.段世博5.郗艳国6.梁赞","初步明确BCAR4在胶质瘤组织及细胞系中的表达水平，初步确定其作为胶质瘤临床筛查或诊断指标的可能性。","Long Non-Coding RNA BCAR4 Promotes Growth,\nInvasion and Tumorigenicity by Targeting miR-2276\nto Upregulate MMP7 Expression in Glioma","王志峰 王龙龙 梁赞 郗艳国","Onco Targets and Therapy","2019-12-01","Short-and long-term effcacy of sustained-release\nchemotherapy in tumor bed interstitium combined\nwith surgical resection for recurrent malignant glioma","王龙龙王志峰梁赞李国京段世博郗艳国","Am J Transl Res","2022-08-30"]
[7,"MicroRNA-610通过靶向基因LRP6抑制黑色素瘤的生长的相关研究","2023年度河北医学科技奖二等奖","沧州市中心医院  1","1.张广静，2.王正想，3.刘杰，4.冯世军，5.季姗姗","进一步明确了Micro-610与LRP6的关系，为黑色素瘤的治疗提供新的治疗思路.","LINC00511 promotes melanoma progression by targeting miR-610/NUCB2","张广静，王正想，刘杰，冯世军，季姗姗，艾东方","Open Medicine","2023年3月\n","miRNA-633 and KAI1 as Potential Biomarkers of Malignant Melanoma with Gastric Cancer","王正想，张广静，杨秀芳，冯世军，季姗姗，齐亚宾","COMBINATORIAL CHEMISTRY &HIGH THROUGHPUT SCREENING","2023-01-01","IncRNA LOC572558对恶性黑素瘤细胞增殖及侵袭的影响","王正想，杨秀芳，季姗姗，张广静，冯世军","现代肿瘤医学","2022-10-01"]
[8,"阿帕替尼联合放化疗治疗小细胞肺癌的临床疗效观察","2023年度河北医学科技奖一等奖","沧州市中心医院","李哲，张菁华，高敬华，李永生，赵瑾","对比了阿帕替尼联合放化疗与放化疗治疗小细胞肺癌疗效及MMP-9水平变化","阿帕替尼联合放化疗不能切除小细胞肺癌的临床疗效","李哲，高敬华，李永生，赵瑾","中华肺部疾病杂志","2023-06-25","干扰ENST00000415026负调控miR-653增强小细胞肺癌对阿帕替尼的敏感性","李哲，柳志宝，孙震，李华蕊","中国老年学杂志","2022-08-25","Efficacy and safety of apatinib alone or apatinib plus paclitaxel/docetaxel versus paclitaxel/docetaxel in the treatment of advanced non-small cell lung cancer:A meta-analysis.","李哲，柳志宝，吴媛媛，李华蕊，孙震，韩承刚，张晓玲，张菁华","Thorac Cancer","2021-11-01","Involvement of ZDHHC9 in lung adenocarcinoma:regulation of PD-L1 stability via palmitoylation.","李哲，姜达，刘风玲，李颖","IN VITRO CELLULAR &DEVELOPMENTAL BIOLOGY-ANIMAL.","2023-03-01"]
[9,"细胞因子与骨髓增殖性肿瘤发病机制的研究","2023年度河北医学科技奖二等奖","沧州市中心医院","尹凤雷，许卫星，李淑晨，张薇，王娟","本研究利用对不同时期骨髓增殖性肿瘤多种细胞因子的研究，能较好地反应患者的发病机制及真实预后，指导个体化治疗，促进分子靶向药物的开发。多细胞因子检测可筛选应用于临床治疗的单克隆抗体和评判疾病进展的标记物，为及时、有效的二线干预治疗提供依据。","NSE、VEGF、MMP-9在MPN患者血清中变化的临床意义","尹凤雷，尹娟，赵芳，张睿，刘静，张薇，李淑晨，王娟","实用癌症杂志","2020-04-25","骨髓增殖性肿瘤患者NGAL、VEGF、PC及PS表达水平及意义研究","尹凤雷，许卫星，李淑晨，张薇，王娟，马洪玉，赵芳，刘静","临床和实验医学杂志","2022-01-20","Analysis of the clinical significance and safety of interferon in the treatment of chronic myeloproliferative tumors","尹凤雷，尹娟，许卫星，李淑晨，张薇，王娟","Journal of Oncology","2022-05-16"]
[10,"下调miR-17对Bax、Mcl-1的表达探讨顺铂对口腔癌细胞的调控机制","2023年度河北医学科技奖一等奖","沧州市中心医院  1","1.孙洋，2.邱波，3.杨琪，4.聂巍，5.郭香君","miR-17水平的变化与口腔癌临床病理及淋巴结转移息息相关，研究miR-17对口腔癌治疗具有可行性.","FBXW7 affects autophagy through MCL1 in oral squamous cell carcinoma","孙洋，聂巍，邱波，杨琪，赵欢欢","Oral Disease","2022；00:1-9","FBXW7 promotes autophagy and inhibits proliferation of oral squamous cell carcinoma","邱波，孙洋，聂巍，杨琪，郭香君","Immunity,Inflammationand Disease","2023;1-9","Inhibition of microRNA-17 enhances cisplatin-induced apoptosis of human tongue squamous carcinoma cell","孙洋，聂巍，邱波，郭香君，张建，魏俭铭","Journal of Bioenergetics and Biomembranes","2021；53:169-176","FBXW7 Enhances Cisplatin-Induced Apoptosis in Oral Cancer Cell Lines","杨琪，孙洋，邱波，赵欢欢","Internarional Dental Journal","(2022)1-8;"]
[11,"基于雌激素和免疫的2型糖尿病骨质疏松预测模型构建","2023年度河北医学科技奖一等奖","沧州市中心医院","1.吴学伦 2.翟福瑞 3.常爱玲 4.魏静 5.郭亚楠","通过整合2型糖尿病患者的临床信息、免疫学指标等多个方面的数据，采用机器学习算法构建骨质疏松预测模型","Application of machine learning algorithms to predict osteoporosis in postmenopausal women with type 2 diabetes mellitus","吴学伦，翟福瑞，常爱玲，魏静，郭亚楠，张金成","Journal of Endocrinological Investigation","2023-05-12","Development of Machine Learning Models for Predicting Osteoporosis in Patients with Type 2 Diabetes Mellitus-A Preliminary Study","吴学伦，翟福瑞，常爱玲，魏静，郭亚楠，张金成","Diabetes, Metabolic Syndrome and Obesity","2023-06-30","Association between sensitivity to thyroid hormone indices and osteoporosis in euthyroid patients with type 2 diabetes mellitus","吴学伦，翟福瑞，常爱玲，魏静，郭亚楠，张金成","Ther Adv Chronic Dis","2023-08-01"]
[12,"儿童系统性红斑狼疮外周血自噬相关基因Beclin1的表达及研究","2023年度河北医学科技奖二等奖","沧州市中心医院","1.刘志明2.郜苗苗3.邵丽丽4.朱翠敏5.刘秀芬","1、首次关注儿童SLE中自噬相关基因Beclin-1等的表达变化和观察透射电镜下单核细胞内自噬体的形态及数量的变化。","SLE患儿外周血自噬相关基因的表达与疾病发生及活动水平的关系","刘志明郜苗苗邵丽丽朱翠敏刘秀芬","川北医学院学报","2021-05-08","TLR9mRNA表达水平与SLE患者病情及疾病进展的相关性","刘志明郜苗苗邵丽丽朱翠敏刘秀芬","分子诊断与治疗杂志","2021-06-01","系统性红斑狼疮患儿中性粒细胞亚群与外周血自噬相关基因Beclin1表达水平相关性","刘志明郜苗苗邵丽丽朱翠敏刘秀芬","分子诊断与治疗杂志","2021-10-01","DUSP1 regulates neuronal damage in epilepsy rats via ERK12 pathway","邵丽丽郜苗苗宫经新杨利永","JOURNAL OF CHEMICAL NEUROANATOMY","2021-12-01"]
[13,"肿瘤及外周血标记物对乳腺癌新辅助化疗反应性的评估价值","2023年度河北医学科技奖一等奖","沧州市中心医院","刘永红、薛玲博、靳健、张博","2、通过实验证明自噬调控可参与SLE的发病，可提示患者预后且有可能成为治疗靶点。","治疗前全身炎症反应指数\n对乳腺癌新辅助化疗病理\n完全缓解的预测价值","刘永红、薛玲博、白\n杨、靳健、臧春霞、\n张博、李杰","国际肿瘤学杂志","2022-04-08","随机森林预测模型的构建\n及其对乳腺癌新辅助化疗\n病理完全缓解的预测价值","靳健,刘永红,张博","肿瘤研究与临床","2022-10-28","Diagnostic Performance\nof Strain and Shear Wave\nElastography for the\nResponse to Neoadjuvant\nChemotherapy in Breast\nCancer Patients:\nSystematic Review and\nMeta-Analysis","靳健,刘永红,张博","Journal of\nultrasound in\nmedicine","2021-12-30","Diffuse optical\nspectroscopy for\nmonitoring the\nresponses of patients\nwith breast cancer to\nneoadjuvant\nchemotherapy: A\nmeta-analysis","刘永红，薛玲博，杨\n艳芳，赵天娇，白杨，\n张步勇，李杰","Medicine\n(Baltimore)","2018-10-15","Aldehyde dehydrogenase\n1 as a predictor of the\nneoadjuvant\nchemotherapy response\nin breast cancer:A\nmeta-analysis","李杰，张博，杨艳芳，\n靳健，刘永红","Medicine\n(Baltimore)","2018-08-10"]
[14,"神经内镜辅助经蝶手术治疗复发垂体瘤的效果及相关因素","2023年度河北医学科技奖一等奖","沧州市中心医院","1.王希瑞2.胡长伟3.李亚斌4.韩晓勇5.任宝文","1.垂体瘤经鼻蝶术后复发的相关因素包括首次手术时肿瘤的侵袭性和肿瘤的切除程度；2.对于复发垂体腺瘤的手术治疗，神经内镜相对于显微镜更有优势；3.环状RNA hsa_circ_0043459的高表达是垂体腺瘤术后复发的风险因素之一。","神经内镜与显微镜经鼻蝶手术治疗复发垂体腺瘤效果比较","胡长伟、王希瑞、李亚斌、韩晓勇、任宝文、尹港峰","河北医药","2022-08-26","垂体腺瘤环状RNA Hsa_circ_0043459表达水平与术后复发的相关性","胡长伟、王希瑞、李亚斌、任宝文、韩晓勇、尹港峰","河北医药","2023-05-10","Chemotherapy of Capecitabine plus Temozolomide for Refractory Pituitary\nAdenoma after Tumor Resection and Its Impact on Serum Prolactin, IGF-1, and\nGrowth Hormone\n","王希瑞、胡长伟、李亚斌、任宝文、尹港峰","JOURNAL OF ONCOLOGY","2022-03-21","Targeting pituitary adenomas with folate-conjugated multiple drug decorated\nliposomal formulations for improved antiproliferative anticancer efficacy\n","胡长伟、王希瑞、李亚斌、韩晓勇、任宝文、尹港峰","JOURNAL OF EXPERIMENTAL NANOSCIENCE","2022-01-01","To explore the change of motor cognitive function in pituitary tumor rats after\noperation\n","胡长伟、李亚斌、韩晓勇、尹港峰、王希瑞","COMPUTER ASSISTED SURGERY","2023-12-31"]
[15,"槲皮素对创伤性脑损伤大鼠皮层神经元的保护作用及其机制研究","2023年度河北医学科技奖一等奖","沧州市中心医院","1.杜国良2.宋建抢3.刘彬4.吴海云5.李宗豪6.赵宗茂7.田耀辉","1.采用槲皮素或槲皮素+LY294002应用于大鼠创伤性脑损伤，观察其对大鼠神经功能恢复的影响2.探讨槲皮素在创伤性脑损伤中发挥神经保护作用的机制3.首次探讨ERK1/2以及PI3K/Akt信号通路在槲皮素的神经保护中的作用","Quercetin\nattenuates neuronal autophagy and apoptosis in rat traumatic brain injury model\nvia activation of PI3K/Akt signaling pathway","杜国良；赵宗茂；陈永汉；李宗豪；田耀辉；刘志峰；刘彬；宋建抢","Neurological Research","2016-10-03","Quercetin protects rat\ncortical neurons against traumatic brain injury","杜国良；赵宗茂；陈永汉；李宗豪；田耀辉；刘志峰；刘彬；宋建抢","Molecular Medicine Reports","2018-03-28","Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats","刘彬；张刚；崔述坤；杜国良","Brain and Behavior","2020年9月21"]
[16,"Er： YAG激光联合生物活性材料在直接盖髓术中的临床研究","2023年度河北医学科技奖二等奖","沧州市中心医院","1.葛超 2.褚亚辉 3.曹素敏 4.魏俭铭","1.激光去腐后，粘接作用更强。2.激光联合使用生物活性材料可提高直接盖髓术的成功率","Er： YAG激光联合 iRoot BP Plus 用于深龋露髓恒牙直接盖髓术中的效果分析","葛超 褚亚辉 曹素敏 魏俭铭","临床误诊误治","2022-08-22","Er： YAG激光和传统去腐对两种粘接系统粘接性能的影响","葛超 魏俭铭 褚亚辉","中华老年口腔医院杂志","2021-11-20","Nd ：YAG 激光联合生物活性材料在直接盖髓术中的临床研究","葛超 褚亚辉","粘接","2022-06-15","LncRNA FGD5-AS1 promotes tumor growth by regulating MCL1 via sponging miR-153-3p in oral cancer","葛超 董家丽 褚亚辉 曹素敏 张静 魏俭铭","AGING-US","2020-07-16"]
[17,"茶碱抑制慢性阻塞性肺疾病模型大鼠炎性反应的机制研究","2023年度河北医学科技奖三等奖","沧州市中心医院1","1.张欣2.杜文秀3.刘芳4.张颖5.杜俊凤","（1）制备鼠模型研究 COPD 的形成与外部环境交互作用，以及 COPD 的发病机制提供有价值的实验数据及理论。（2）本研究采用被动吸烟和气道内滴入 LPS，模拟人类的吸烟加感染的 COPD 病因，更贴近实际。建立 COPD 大鼠模型以观察在不同时间段大鼠肺功能及气道肺组织病理变化规律，为进一步研究被动吸烟的时间长短与 COPD 的发生、发展规律奠定研究基础。（3）研究同时考察了肺功能、血液、支气管 BALF 细胞计数等多个方面的指标，全面评价了氨茶碱治疗 COPD 的效果。 ","氨茶碱对慢性阻塞性肺疾病大鼠肺功能的改善作用","张欣，杜文秀，刘芳，杜俊凤，张颖，迟玉敏","中华实用诊断与治疗杂志","2021-09-01","氨茶碱对慢性阻塞性肺疾病大鼠气道重塑的影响","杜文秀，张欣，刘芳，杜俊凤，张颖，迟玉敏","西北药学杂志","2022-12-01","氨茶碱对脂多糖诱导的慢性阻塞性肺疾病大鼠肺功能的作用","刘芳，杜文秀，张欣，杜俊凤，张颖，迟玉敏","西北药学杂志社","2022-12-01"]
[18,"院外心搏骤停患者心肺复苏成功的影响因素及预测方法","2023年度河北医学科技奖一等奖","1.沧州市中心医院；2.沧州市人民医院","1.王文杰2.刘颖3.杨风梅4.马宝重5.李勇","1.血 清 神 经 丝 轻 链预测心搏骤停患者预后","血清神经丝轻链对院外心搏骤停患者神经功能的预测价值","杨风梅,马宝重,孙\n强,李楠,刘颖,王\n文杰","中华急诊医学杂志","2023-03-10","院外心脏骤停患者出院存活的\n危险因素与列线图预测模型构\n建","杨风梅,冯顺易，王\n文杰，李勇","中国急救医学","2022-12-10","Prognostic Values of the\nGray-to-White Matter Ratio\non Brain Computed\nTomography Images for\nNeurological Outcomes after\nCardiac Arrest: A\nMeta-Analysis","王文杰，崔杰，吕\n广卫，冯顺易，赵\n勇，张素丽，李勇","BioMed research\ninternational","2020-11-03","视神经鞘直径预测心搏骤停患者预后的 meta 分析","杜雨森,王文杰,冯\n顺易,李勇.","临床急诊杂志","2020-10-10"]
[19,"平鳍式种植体与螺纹式种植体临床差异的回顾性研究","2023年度河北医学科技奖三等奖","沧州市中心医院"," 1.许可 \n2.代晓娟\n3.温凯","平鳍式种植体结构独特，对患者的预后较好，经济负担轻，生物相容性好，与螺纹式种植体相比具有较大的优势","平鳍式种植体与常规螺纹式种植体的临床疗效对比分析","许可，代晓娟，温凯","中国美容医学"," 2022 年 12 月 10 日","平鳍式种植体与螺纹式种植体对口腔种植患者经济负担与并发症的影响","代晓娟，温凯，许可","中国美容医学","2023 年 3 月 10 日","螺纹式种植体联合正畸治疗先天缺牙疗效观察","温凯，代晓娟，许可","中国美容医学","2023 年 1 月 10 日"]
[20,"影响颅内动脉机械取栓术后患者良好预后率的相关因素分析","2023年度河北医学科技奖一等奖","沧州市中心医院","1.刘永昌2.洪震3.郑明明4.谢松旺5.刘庆冉","1．通过比较神经功能评分、血清因子水平、血管再通率、不良反应发生率、心肌梗死溶栓（ TIMI ）分级流量和治疗有效率，发现静脉溶栓（重组组织型纤溶酶原激活剂）联合机械血栓切除术可加速 ACI 患者的神经功能恢复，减少不良反应，提高血管再通率。2．研究结果提示：高龄、既往糖尿病、入院时高 NHISS评分、责任血管为椎-基底动脉是急性大血管闭塞性缺血性卒中血管内机械取栓术后预后的不良影响因素。其中高龄、入院时高NHISS评分与既往研究结果类似，但本研究发现糖尿病患者预后更差，有利于指导患者的术前评估，提示临床重视术后患者的血糖管理；责任血管为椎-基底动脉预后更差，说明对于后循环梗死患者的术前评估更需慎重。","Effect of intravenous\nthrombolysis combined with mechanical thrombectomy on neurological function and\nshort-term prognosis of patients with acute cerebral infarction","刘永昌，洪震，李严，李少泉，刘庆冉，谢松旺，王俊勇，王健，郑明明","American journal of\ntranslational research","2022-04-15","Effect of Pathogenesis-Based\nIndividualized Thrombectomy on Treatment Result and Prognosis of Acute\nIntracranial Large-Artery Occlusion Patients","刘永昌，郑明明，李严，谢松旺，刘庆冉，王俊勇","Turk Neurosurg","2022-07-20","RNF216 Alleviates Radiation-Induced\nApoptosis and DNA Damage Through Regulating Ubiquitination-Mediated Degradation\nof p53 in","谢松旺，洪震，李严，王俊勇，王健，李少泉，刘永昌","Molecular neurobiology","2022-05-20","PUM2 aggravates the neuroinflammation and brain damage induced by ischemia-reperfusion through the SLC7A11-dependent inhibition of ferroptosis via suppressing the SIRT1","刘庆冉，刘永昌，洪震，李严，李少泉，刘晨","Molecular and cellular\nbiochemistry","2022-08-23","Combining machine learning\nwith radiomics features in predicting outcomes after mechanical thrombectomy in\npatients with acute ischemic stroke","李严，刘永昌，洪震，王英，路秀玲","Computer methods and\nprograms in biomedicine","2022-08-28","急性大血管闭塞性缺血性卒中患者机械取栓术后预后影响因素分析","刘永昌;郑明明;李严;谢松旺;王俊勇;刘庆冉","中国现代神经疾病杂志","2020-05-25","老年脑梗死后病人继发脑出血与血清同型半胱氨酸及肿瘤坏死因子水平相关性分析","洪震;王丽轩;张丽冉;郭建;黄少越;张俊玲","实用老年医学","2020-06-20"]
[21,"沧州地区儿童急性呼吸道感染病毒病原检测分析","2023年度河北医学科技奖二等奖","沧州市中心医院","1.谢菲 2.蔡永艳 3.伊文霞 4.杨磊 5.闫志新","首次对沧州地区ARIs住院患儿的病毒病原进行监测分析，为即时、准确地掌握急性呼吸道感染的病原学及分布，对疾病的预防和治疗提供参考。","MicroRNA-194 Regulates Lipopolysaccharide-Induced Cell Viability by In activation of Nuclear Factor-kB Pathway","谢菲 杨磊 韩丽丽 岳彬","Cell Physiology and Biochemistry","2017-10-31","Broad-spectrum antiviral effect of Chebulagic acid and punicalagin on respiratory sync y to all virus infection in a BALB/c model","谢菲","International Journal of Clinical and Experimental Pathology","2016-02-01","儿童急性呼吸道感染病毒病原检测741例分析","谢菲 蔡永艳 杨磊 岳彬","中国儿童保健杂志","2015-10-01"]
[22,"血清胱抑素C与缺血性脑血管病患者颈动脉粥样硬化的相关性研究","2023年度河北医学科技奖二等奖","沧州市中心医院","1.贾建普2.张乐国3.王丽轩4.夏瑞雪5.姬春雪","1.本项目发现血清胱抑素C与颈动脉重度狭窄相关;2.本项目发现血清chemerin与ICVD患者脑动脉狭窄程度相关;3.本项目发现丁苯酞通过改善chemerin水平改善神经功能缺损;4.本项目发现血清OX40L、Occludin可作为评估ICVD预后的生物学标记。","血清胱抑素C与颈动脉狭窄程度的相关性研究","贾建普 王丽轩 张乐国 姬春雪 张俊玲","中国动脉硬化杂志","2014-06-01","恩必普治疗对ICVD患者血液流变学、血清chemerin和Hcy水平的影响","王丽轩 洪震 张乐国 贾建普 张俊玲","分子诊断与治疗学","2020-06-01","血清趋化素及同型半胱氨酸水平与缺血性脑血管病患者血管狭窄程度的相关性研究","王丽轩 洪震 张乐国 贾建普 张俊玲","中国医药","2020-08-01","血清OX40L、Occludin与急性缺血性脑卒中患者病情程度及预后的相关性研究","贾建普 张乐国 王丽轩 姬春雪 夏瑞雪 张俊玲","国际检验医学杂志","2022-03-14","CTA评估缺血性脑血管病患者颈动脉粥样硬化程度与Cys-C、Hcy指标相关性分析","贾建普 张乐国 王丽轩 姬春雪 夏瑞雪 张俊玲","中国CT和MRI杂志","2022-03-01","Analysis of the expression levels of chemerin,ox-LDL,MMP-9,and PAPP-A in ICVD patients and their relationship with the severity of neurological impairment","贾建普 王丽轩 张丽冉 洪震 夏瑞雪 赵泽宇 张乐国","Brain and Behavior","2022-05-26"]
[23,"Tei指数与SCUBE1联合校正的D二聚体在老年人肺栓塞诊断中的价值探讨","2023年度河北医学科技奖二等奖","1.沧州市中心医院;2.河北省沧州监狱医院","马育霞，杨梅，刘毅，王文浩","国内首次联合校正D二聚体、Tei指数和SCUBE1对肺栓塞的诊断进行预测；国内首次选择微信联合互联网对老年肺栓塞口服华法林进行出院后随访。","Risk factors of pulmonary embolism in the elderly patients: a retrospective study ","马育霞、刘毅、支莹、王海滨、杨梅、牛洁婷、赵莉、王鹏升","Aging clinical and experimental research","2022-05-01","Predictive Value of Combined Plasma D-Dimer,SCUBE1,and Right Ventricular Tei Index for the Prognosis of Elderly Patients with Acute Pulmonary Thromboembolism.","杨梅，刘毅，马育霞，王文浩","Rejuvenation Reseach","2023-02-01","Inhibitors of IFN gene stimulators (STING) improve intestinal ischemia– reperfusion-induced acute lung injury by activating AMPK signaling.","杨梅、马育霞、支莹、王海滨、赵莉、王鹏升、牛洁婷","European Journal of Medical Research","2022-05-31"]
[24,"视黄醇结合蛋白4与急性缺血性脑卒中患者CT灌注成像及患者预后的相关性研究","2023年度河北医学科技奖一等奖","1.沧州市中心医院2.沧州医学高等专科学校","1.刘超2.谷聚贤3.姚彦4.户红伟5.郭萍","1、本项目证实了RBP4表达水平可以预测急性缺血性脑卒中的动脉粥样硬化的发展过程及损伤程度。2、本研究证实了CT灌注成像能够在短时间内准确地鉴别急性缺血性脑卒中核心梗死区（不可逆性）与缺血半暗带区（可逆性）。3、RBP4表达水平与CT灌注联合检测能够有助于评估急性缺血性脑卒中患者溶栓前后的各项神经功能指标。","Correlation between Retinol Binding Protein 4 and CT Perfusion Imaging and Prognosis in Patients with Acute Ischemic Stroke Based on Cell Imaging Data Analysis","刘超 谷聚贤 姚彦 户红伟 郭萍","CONTRAST MEDIA&MOLECULAR IMAGING","2022-08-01","小檗碱对大鼠急性脑梗死的治疗作用及其机制","姚彦、谷聚贤、赵丽、李猛、艾静怡、刘超","山东医药","2023-04-25","Longitudinal Change of Plasma Retinol-Binding Protein 4 and its Relation to Neurological-Function Recovery, Relapse, and Death in Acute Ischemic Stroke Patients","刘超、谷聚贤、姚彦","TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE","2023-08-01","Retinol-Binding Protein 4 Predicts Lesion Volume (Determined by MRI) and Severity of Acute Ischemic Stroke","刘超 车延旭","Neurotoxicity Research","2020-01-01","MiR-485-3p modulates neural stem cell differentiation and proliferation via regulating TRIP6 expression","谷聚贤、邵汝升、李猛、闫秋月、户红伟","JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","2020-01-01"]
[25,"甲状腺过氧化物酶抗体与2型糖尿病慢性并发症相关性研究","2023年度河北医学科技奖二等奖","沧州市中心医院\n\n1.沧州市中心医院","1.杨洁 2.丁文萃 3.王海英 4.史亚男","首次以TPO-Ab数值分组，收集临床资料，分析TPO-Ab与2型糖尿病慢性并发症相关性。证实TPO-Ab可能影响2型糖尿病慢性并发症的发生发展，并深入探讨其结果产生的机制。通过收集临床动态血糖监测数据，构建2型糖尿病慢性并发症风险列线图预测模型，可预测2型糖尿病慢性并发症发生风险，为临床设定血糖目标和选择降糖方案提供指导意义。通过利用广义相加模型进行平滑曲线拟合，分段逻辑回归模型分析游离甲状腺素与糖尿病视网膜病变之间的阈值效应。","含动态血糖分析的2型糖尿病慢性并发症风险预测模型及效能评价","杨洁 丁文萃 王海英 史亚男","疑难病杂志","2022-08-18","甲状腺过氧化物酶抗体与2型糖尿病下肢血管病变的相关性研究","杨洁，丁文萃，王海英，史亚男","河北医科大学学报","2023-02-01","Association Between Sensitivity to Thyroid Hormone Indices and Diabetic Retinopathy in Euthyroid Patients with Type 2 Diabetes Mellitus","Jie Yang ,Wencui Ding, Haiying Wang, Yanan Shi","DIABETES METABOLIC SYNDROME AND OBESITY","2023-02-27"]
[26,"药物注射联合手术对颞下颌关节病的诊治分析","2023年度河北医学科技奖一等奖","沧州市中心医院","1.魏校通 2.闫威 3.孙安君 4.王浩 5.王伟","对于接受颞下颌关节盘复位固定术患者，术前加用透明质酸钠关节腔注射，能够增加关节盘复位固定术后有效率及患者主动张口度，减轻关节区疼痛，还会降低颞下颌关节病炎性因子IL-1β和IL18的含量。","单侧颞下颌关节病患者与无症状侧关节MRI异常的相关性研究","魏校通，闫威，孙安君，王浩，王伟，闫冰","河北医药","2022-11-01","Exosomal miR-130b-3p Promotes Progression and Tubular Formation Through Targeting PTEN in Oral Squamous Cell Carcinoma","闫威，王玉平，陈勇，郭燕军，李强，魏校通","Frontiers in Cell and Developmental Biology","2021-03-01","Effect of different doses of apatinib mesylate combined with chemotherapy on advanced oral cancer","闫威，闫佳煊，陈勇，李强，郭燕军","American Journal of Translational Research","2021-12-01"]
[27,"血清维生素D水平与缺血性脑卒中相关性研究","2023年度河北医学科技奖二等奖","沧州市中心医院\n\n1.沧州市中心医院","1张海柳2杨国涛3李聪慧4王文慧5王春雨","1、率先建立了脑梗死患者血清维生素D 水平与神经功能缺损相关性的预测型且发现具有良好的预测效率。2、提出血清维生素D与血管内皮钙黏蛋白联合检测可提升脑梗死不良预后的预测准确性。3、率先发现血清维生素D水平降低是老年缺血性脑卒中患者静脉溶栓后发生出血转化的独立危险因素。","血清TN- C、Irisin 与急性缺血性脑卒中患者病情严重程度和预后的关系","张海柳 杨国涛 李聪慧 王文慧 王春雨 董爱勤","中风与神经疾病杂志","2020-12-30","血清血管内皮钙黏蛋白、25-羟基维生素D水平与急性缺血性脑卒中病人病情及预后的关系","杨国涛 张海柳 李聪慧 王文慧 \n王春雨 王芳 董爱勤 ","中西医结合心脑血管病杂志","2022-03-10","血清维生素D 水平与老年缺血性脑卒中患者静脉溶栓后出血转化的影响","杨国涛 张海柳 李聪慧 王文慧 \n王春雨 王芳 董爱勤 ","中国老年学杂志","2022-06-10","Prediction Model between Serum Vitamin D and Neurological Deficit in Cerebral Infarction Patients Based on Machine Learning","张海柳 杨国涛 董爱勤","Comput Math Methods Med","2022-06-28","Risk factors for cognitive impairment in patients with first-time ischemic stroke","杨国涛  李聪慧 王文慧  王春雨\n董爱勤  王芳 张海柳","Am J Transl\n Res","2021-03-30"]
[28,"肩胛上悬吊复合体（SSSC）双重损伤的治疗方式的选择","2023年度河北医学科技奖二等奖","沧州市中心医院\n\n1.沧州市中心医院","1.杨磊 2.单忠林 3.张娜 4.谢菲 5.金驰","1.明确SSSC双重损伤患者手术治疗及保守治疗的适应症选择标准。2.评估保守治疗与手术治疗SSSC双重损伤的临床疗效。","Down regulation of Home box B7 Inhibits the Tumor Genesis and Progression of Osteosarcoma","杨磊 谢菲 李双庆","Oncology Research","2017-09-11","Myricitrin decreases traumatic injury of the spinal cord and exhibits antioxidant and anti-inflammatory activities in a rat model via inhibition of COX-2，TGF-β1，p53 and elevation of Bcl-2/Bax signaling pathway","杨磊","Molecular Medicine Reports","2017-03-21","腋旁入路锁定接骨板治疗不稳定性肩胛颈骨折的疗效分析","杨磊 谢菲 宋昆 刘宁 金驰 单忠林","中国医学装备","2014-12-11","肩胛上悬吊复合体双重损伤联合固定的疗效分析","杨磊 谢菲 张娜 宋昆 刘宁 单忠林","中国医学装备","2014-12-11"]
[29,"早期帕金森病患者嗅觉与认知障碍的特点及其相关性研究","2023年度河北医学科技奖二等奖","沧州市中心医院","1.白雪 2.董巧云 3.赵丽 4.姚彦 5.王博","探讨早期帕金森病患者嗅觉障碍与认知障碍的相关性，寻找能够反映早期帕金森病患者认知功能损害的临床标志物","帕金森病患者血清miR-103a-3p、miR-486-5p水平变化及临床意义","白雪；董巧云；王博；赵丽；姚彦","山东医药","2022-02-05","帕金森病患者血清miR-7和α-Syn表达水平与认知功能障碍的相关性研究","白雪；董巧云；赵丽；姚彦；王博","现代检验医学杂志","2023-07-30","microRNA-106b-containing extracellular vesicles affect autophagy of neurons by regulating CDKN2B in Parkinson's disease.","白雪 董巧云 赵丽 姚彦 王博","Neurosci Lett ","2021-08-24"]
[30,"分泌性白细胞蛋白酶抑制因子在结直肠癌中的表达及其临床意义","2023年度河北医学科技奖一等奖","沧州市中心医院","1.魏志江2.刘桂英3.贾汝福4.张维5.李丽6.张媛媛7.王芝静8.白希永","1.联合运用组织芯片及免疫组化技术证实SLPI高表达与结直肠癌低分化、TNM分期III-IV期、淋巴结转移及远处转移显著相关，是结直肠癌靶向药物治疗的新靶点。2，联合运用组织芯片及免疫组化技术证实SLPI在癌旁正常粘膜低表达，随着结直肠癌的低分化、TNM分期III-IV期、淋巴结转移及远处转移SLPI出现高表达，证实SLPI在结直肠癌的早期治疗及早期诊断方面进行积极探索。","Expression of secretory leukocyte protease inhibitor detected by immunohistochemistry correlating with prognosi and metastsis in colorectal","刘桂英杨景艳赵玉磊王芝静邢宝恒王亮石东亮","world Journal of Surgical Oncology","2014-12-02","Targeting secretory leukocyte protease inhibitor（SLPI）inhibits colorectal cancer cell growth,migration and invasion via downreguation of AKT","魏志江刘桂英贾汝福张维李丽张媛媛王芝静白希永","DOI 10.7717/peerj.9400.","2020-07-14","Up-regulation of microRNA-302a inhibited the proliferation and invasion of colorectal cancer cells by regulation of the MAPK and PI3K/Akt signaling pathways","魏志江陶明玲韩国达朱中成苗志刚李建业乔占兵","Int J Clin Exp Pathol","2015-04-21","Inhibition of secrrtory leukocyte protease inhibitor（SLPI）promotes the PUMA-mediated apoptosis and chemosensitivity to cisplatin in colorectal cancer cells.","魏志江刘桂英贾汝福张维李丽张媛媛王芝静白希永","Discover oncology","2023-01-03"]
[31,"IncRNA CASC11调控胶质瘤细胞增殖凋亡和迁移侵袭及其分子机制研究","2023年度河北医学科技奖二等奖","1.沧州市中心医院 2.唐山市工人医院 3.邯郸市第一医院\n","1.赵志煌 2.祁大勇 3.刘军 4.李刚 5.韩永刚","1.发现了CASC11-miR-64-1- AKT3调控通路对胶质瘤细胞增殖、迁移和侵袭的抑制作用。2.阐明了 CASC11-miR-641-AKT3通路抑制胶质瘤细胞增殖、迁移和侵袭的调控机制。","CASC11通过调控miR-641的表达对脑胶质瘤细胞恶性生物学行为的作用机制研究","1.赵志煌 2.祁大勇 3.刘军 4.李刚 5.韩永刚","卒中与神经疾病","2022-06-26","青藤碱基于CASC11/AKT3轴对脑胶质瘤原位荷瘤裸鼠肿瘤生长及血管生成的抑制作用","1.祁大勇 2.刘军 3.赵志煌 4.李刚 5.韩永刚","广西医学","2022-06-30","八月札水提物对胶质瘤细胞EMT的作用机制研究","1.刘军2.祁大勇3.赵志煌4.李刚5.韩永刚","河北医学","2022-02-28","Circular RNA ZNF609 enhances proliferation and glycolysis during glioma progression by miR-378b/SLC2A1 axis","1.赵志煌2.李刚3.韩永刚4.李亚斌 5.纪执胜6.郭瑞7.于晓红","AGING-US","2021-09-14"]
[32,"可调节高腰矫形鞋在防治中枢神经功能障碍患者足继发畸形中的作用","2023年度河北医学科技奖一等奖","沧州市中心医院","贾汝福；王芝静；王路；王希瑞；刘洁琼","改良矫形器设计和材质，拓展其功能，增设动力辅助运动结构和监测结构，使其更易操作，价格更低，动静两用，耐用舒适，可有效预防医疗器械相关性压力性损伤，同时证实可调节踝足矫形器应用于脑卒中和脊髓损伤患者，配合传统理疗方法可有效减少足继发畸形的发生率，和提高下肢功能康复率，改善患者运动、平衡、步行功能，提高日常活动能力。","可调节踝足矫形器配合针灸对脑出血偏瘫患者足畸形及步行能力的影响","王希瑞；张静；孙杰；王芝静；贾汝福","中国康复","2019-10-25","新型矫形高腰鞋在预防脊髓损伤患者足下垂畸形中应用的效果观察","王路；王芝静；孙杰；刘洁琼；王希瑞；贾汝福","中华现代护理杂志","2019-06-06","新型矫形高腰鞋在急性脑梗死偏瘫患者中的应用效果","刘洁琼；王芝静；王路；孙杰；王希瑞；贾汝福","中国老年学杂志","2022-05-25","智能康复仪在脑卒中偏瘫患者下肢功能康复中的应用","曹明聪；贾汝福；王芝静；李海月；王翠婕；李冰；丁冕磊；黄涛；吴晶晶","中华现代护理杂志","2023-07-06"]
[33,"超声引导Ⅱ型胸神经阻滞在乳腺癌手术加速康复外科中的应用","2023年度河北医学科技奖二等奖","沧州市中心医院","崔秀玲，于丽丽，赵浩晨，刘萍，赵晓琛","将II型胸神经阻滞联合全麻应用于乳腺癌手术中，术后PBMC中NK细胞比例升高，NK细胞杀伤活性升高，抑炎因子IL-2浓度升高，中性粒细胞与淋巴细胞的比例（NLR）降低，降低了手术创伤对机体炎症反应，缓解术后疼痛，减少患者早期不良情绪，有助于早期预后。","超声引导下II型胸神经阻滞对全麻下行乳腺癌手术患者炎性介质水平的影响","崔秀玲，于丽丽，赵浩晨，刘萍，赵晓琛，缴宝杰","河北医药","2020-12-10","超声引导下II型胸神经阻滞对全麻下行乳腺癌手术患者免疫功能的影响","崔秀玲，刘萍，赵晓琛，于丽丽，赵浩晨，缴宝杰","河北医药","2021年3月26","II型胸神经阻滞联合艾司氯胺酮对全麻乳腺癌手术患者焦虑抑郁情绪的影响","于丽丽，周琦，李伟，宋盼盼，李春雷，张勤，崔秀玲，常玉林","中华麻醉学杂志","2022年7月20","Effect of pectoral nerve block type II under general anesthesia on the immune function of patients with breast cancer","崔秀玲，朱翠女，陈鹏，瞿敏，张博伟，李洪涛","The American Journal of Surgery","2020-10-01","Perioperative pectoral nerve block type II and postoperative recurrence in breast cancer: a randomized controlled trial","于丽丽，崔秀玲，宋盼盼，李春雷，赵浩晨，常玉林","BMC SURGERY","2022-12-30"]
[34,"两种透析方法治疗糖尿病并重症肾衰竭的分子学评价","2023年度河北医学科技奖三等奖","沧州市中心医院","马晓华 周亚男 王荣荣 聂屾 李石磊","持续肾替代（CRRT）治疗糖尿病并重症肾衰竭改善miRNA30a水平。","持续低效缓慢血液透析治疗终末期糖尿病肾病临床观察","马晓华，周亚男，王荣荣，聂屾，李石磊，王博，李勇","解放军医药杂志","2019-04-28","连续肾替代与血液透析治疗2 型糖尿病并重症肾衰竭疗效及安全性分析","马晓华，周亚男，王荣荣，聂屾，李石磊，王博，李勇","解放军预防医学杂志","2018-09-30","2 型糖尿病并重症肾衰竭连续肾脏替代治疗临床效果及对血清瘦素和微小RNA30a 水平的影响","马晓华，周亚男，王荣荣，聂屾，李石磊，王博，李勇","临床误诊误治","2019-02-22"]
[35,"脊柱内镜治疗老年多节段脊柱病变及药物的临床研究","2023年度河北医学科技奖一等奖","沧州市中心医院","王路，李凌霞，程才，李维彬，郭志远","应用经皮脊柱内镜技术，结合药物预镇痛等处理，治疗老年多节段脊柱病变，在达到良好治疗效果的同时，还可以大大降低围手术期风险，为治疗老年多节段脊柱病变提供了新的思路。","多通道经皮脊柱内镜手术治疗老年多节段腰椎间盘突出症","王路，程才，李凌霞，李维彬，辛大森，郭志远，韩红敏","中国骨与关节损伤杂志","2023年 3 月","经皮脊柱内镜“隔离区”技术治疗椎间盘源性腰痛的临床疗效观察","\n王路，李凌霞，程才，辛大森，郭志远，李维彬，侯汉辉，韩红","中国临床新医学","2022年 11 月","椎间孔镜 TESSYS 技术治疗单责任节段腰椎管狭窄症的近期结果","程才，辛大森，王路，高书明， 李勇","中国微创外科杂志","2018 年 10 月","The percutaneous spinal endoscopy \"isolation zone\"technique for discogenic low back pain: a case\nseries study.","王路，李凌霞，程才，雪原","EUROPEAN JOURNAL OF MEDICAL RESEARCH.","2022 年 10 月","Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc","王路;李凌霞;程才;郭志远;辛大森;闫新彪;李维彬;韩红敏","JOURNAL OF VISUALIZED EXPERIMENTS","2023 年 4 月"]
[36,"2型糖尿病患者并发牙周炎早期诊断价值","2023年度河北医学科技奖一等奖","沧州市中心医院","1肖遵胜，2丁文萃，3温超，4葛超，5刘璐","通过联合检测T2DM患者牙周指数（包括菌斑指数、牙龈指数、龈沟出血指数、牙周探诊深度）及IL-17A，早期诊断T2DM合并牙周炎，在国内文献中未见相同报道","Correlation between salivary HBD-2 and LL-37 expression levels with blood glucose and periodontal status in patients with type 2 diabetes mellitus","肖遵胜，丁文萃，温超，葛超，刘璐，许可，曹素敏 ","Am J Transl Res","2022-05-28","Correlation between salivary developmental endothelial locus-1, interleukin 17 expression level and severity of periodontal disease in patients with type 2 diabetes mellitus","丁文萃，肖遵胜，温超，葛超，刘璐，许可，曹素敏","Am J Transl Res","2021-10-25","Relationship between microRNA expression and inflammatory factors in patients with both type 2 diabetes mellitus and periodontal disease","刘璐，肖遵胜，丁文萃，温超，葛超，许可，曹素敏","Am J Transl Res","2022-09-28",{"$nulls":4},"Herniation"]
[37,"血清脂联素、脂多糖、基质金属蛋白酶-2联合检测在肝硬化诊疗中的价值","2023年度河北医学科技奖三等奖","沧州市中心医院","1.郭瑞雪2.侯宝洲3.魏新亮4.魏思忱5.史晓盟","1.本研究在国内外研究基础上，采用多指标联合检测，最大程度上弥补单指标检测可能存在的误差和不灵敏2.本科研技术方法简单，可适用于可以开展ELISA法检测的各基层单位","肝硬化患者血清脂联素、脂多糖、基质金属蛋白酶-2水平及其诊断价值","郭瑞雪，魏新亮，史晓盟，魏思忱","中国现代医学杂志",2020.06,"肝硬化患者血清脂联素、脂多糖、基质金属蛋白酶-2水平与病情严重程度相关性分析","郭瑞雪，侯宝洲，魏新亮，史晓盟，张爱青，魏思忱","临床军医杂志",2020.07]
[38,"miR-133a、TPD52差异表达在胰腺癌中的临床意义及其机制研究","2023年度河北医学科技奖一等奖","沧州市中心医院","王振勇、石亮、孟宇、李金超、李凤山","1. 在项目前期研究中首次发现TPD52可参与胰腺癌细胞增殖、凋亡的调节；\n2. 在临床水平明确了胰腺癌中肿瘤蛋白D52、miR-133a的表达及其与患者临床病理特征及预后的关系，明确了miR-133a对胰腺癌生物学行为存在影响，初步论证miR-133a通过靶向TPD52抑制胰腺癌细胞生物学行为的机制。","改良胰肠荷包套入式吻合方式的临床应用","王振勇，李凤山，刘汝海，孔德帅，赵秀雷，张雷","肝胆胰外科杂志","2018-03-01","腹腔镜胰十二指肠切除术后胰漏的相关因素分析","王振勇，刘汝海，李凤山，张执全，袁俊健","中国微创外科杂志","2019-02-01","海德堡三角清扫在腹腔镜胰十二指肠切除术治疗胰腺癌中的近期疗效","王振勇，孟宇，李金超，张雷，石亮，刘汝海，李凤山","中华胰腺病杂志","2021-08-01","肿瘤蛋白D52在胰腺癌组织中的表达及其临床意义","王振勇，孟宇，李金超，张雷，石亮，田亮，刘汝海","肝胆胰外科杂志","2022-02-01","胰腺癌术后局部复发特点及影响因素分析","王振勇，孟宇，李金超，张雷，魏永健，刘唱，王祁平，陈德强，刘汝海","中华普通外科杂志","2022-08-01","Effect of laparoscopic pancreaticoduodenectomy on the incidence of surgical-site wound infection: A meta-analysis","孔德帅，张恒乐，赵秀雷，孟宇，柴伟，王振勇","International Wound Journal","2023-06-05"]
[39,"脐血白细胞、降钙素原、C反应蛋白、红细胞分布宽度与血小板比值对危重新生儿病情及预后评估的价值","2023年度河北医学科技奖二等奖","沧州市中心医院1","1.郭彬芳2.王海燕3.王玉春4.梁秀英5.张春燕6.许萍萍","应用血常规中的红细胞分布宽度与血小板计数比值(RPR)，与新生儿紧急生理 \n评分对比，分析其预测危重新生儿病情变化的价值","Value of red cell distribution width-to-platelet ratio as a predictor for morbidity and mortality in neonatal intensive care unit.","王海燕 王玉春 梁秀英 张春燕 郭彬芳","Clinical Hemorheology\nMicrocirculation","2022-07-26","The association of serum vitamin D level and neonatal respiratory distress syndrome","刘伟力 许萍萍","Italian journal\nOf Pediatrics","2023-01-30","The Nrf2 inhibitor brusatol has a protective role in a rat model of oxygen-induced retinopathy of prematurity","梁秀英 王瑞芬","Visual Neuroscience","2021-03-17"]
[40,"个体化抗血小板治疗用于缺血性卒中的研究","2023年度河北医学科技奖二等奖","沧州市中心医院","李雪艳李海妹裘雪艳赵莎莎刘万根刘金峰","高脂血症高同型半胱氨酸血症，人血浆蛋白相关磷脂酶与抗血小板药物抵抗具有相关性。","1不同抗血小板方案用于缺血性脑血管病患者DSA检查相关并发症的影响效果研究","李雪艳李海妹裘雪艳赵莎莎刘万根刘金峰","1湖南中医药大学学报","2017年11月","2.抗血小板药物个体化治疗对缺血性脑卒中患者的影响","李雪艳 李海妹 裘雪艳 赵沙沙 刘万根 刘金锋","创伤与急危重症医学","2018年2月","3个体化抗血小板治疗缺血性卒中患者疗效及对数字减影血管造影并发症的影响","李雪艳 李海妹 裘雪艳 赵沙沙 刘万根 刘金锋","临床军医杂志","2018年4月"]
[41,"双极电凝系统与超声刀在甲状腺手术中的应用效果","2023年度河北医学科技奖三等奖","沧州市中心医院1","1张步勇2李杰3及彦婷4张旋5薛玲博","1、比较了各种手术器械在甲状腺手术中的应用效果。\n2、通过此研究分析，有利于在甲状腺手术中选择更优的手术器械，在保证手术效果的同时，降低患者负担，避免资源浪费，更易于向广大的基层医院推广。","TEAD4 overexpression suppresses thyroid cancer progression and metastasis in vitro through modulating Wnt signaling","张步勇 王青青 及彦婷 张旋 薛玲博 史清峰 李杰","Indian Academy of Sciences（0250-5991）","2021-11-22","双极电凝系统与超声刀治疗甲状腺癌术后甲状旁腺功能及术后引流液成分的比较","张步勇 及彦婷 张旋 薛玲博 史清峰 李杰","广东医学","2022年10月15 日"]
[42,"气道定植菌在非小细胞肺癌患者术后中的表达","2023年度河北医学科技奖三等奖","1沧州市中心医院2唐山市丰南区医院","1尤雷2刘艳虹3吴国峰4邸庆国","1致病性气道定植菌是造成NSCLC患者术后肺感染的危险因素；2气道定植菌可影响炎症介质表达；3术中行淋巴结清扫，可能可以降低肺感染风险。","非小细胞肺癌患者术后1年生存与呼吸道细菌微生物分布的关系","尤雷，翟俊伟，刘艳虹，吴国峰，邸庆国","解放军医药杂志","2022-07-28","非小细胞肺癌合并下呼吸道感染患者气道定植菌分布及危险因素分析","尤雷，翟俊伟，刘艳虹，吴国峰，邸庆国","临床误诊误治","2022-03-22","呼吸道微生物定植与非小细胞肺癌患者根治术后肺炎发生的相关性分析","尤雷，翟俊伟，刘艳虹，吴国峰，邸庆国","解放军医药杂志","2022-03-28"]
[43,"高压氧结合针灸推拿法对脑卒中患者康复治疗的效果研究","2023年度河北医学科技奖一等奖","沧州市中心医院","芮晨 杨炳健 王欣然\n安松 潘荣","1.从两个单因素和交互因素探讨高压氧治疗和针灸推拿治疗对脑梗死恢复期患者治疗影响效应。\n2.通过计算NIHSS量表和mRs量表等评分从参数和非参数检验两个角度计算评价该治疗手段对脑梗死恢复期患者的治疗效果。\n3.在脑梗死恢复期患者的治疗中采用了中西医互补治疗的方法，并且在实验前运用系统评价法对文献进行总体分析。\n","A study on predicting the\nlength of hospital stay for Chinese patients with ischemic stroke based on the\nXGBoost algorithm.","芮晨，张胜发，李杰，郭栋炜，田东华，王晓英，张维军，曲志勇，王晓华","BMC Medical Informatics and\nDecision Making.","2022-03-22","Nussbaum-type neural\nnetwork-based control of neuromuscular electrical stimulation with input\nsaturation","芮晨，李杰陈银河，张晴","Journal of Computational and Nonlinear Dynamics","2022-01-13","基层医疗卫生机构工作人员离职意愿及其影响因素研究","芮晨，黄磊","中国卫生政策研究","2021-04-25","基于患者动态知识搜索的医生过度医疗行为研究","芮晨, 张胜发,陶富,张维军, 田东华","复杂系统与复杂性科学","2020-06-15","基于LIME-BP神经网络的医疗费用预测研究","芮晨, 张胜发,郭栋炜,李杰","中国卫生统计","2020 年 10 月25日","高压氧联合针灸对脑卒中恢复期患者治疗效果分析","芮晨，王欣然潘荣，梁亮安松，张胜发","河北医药","2021-07-26"]
[44,"右美托咪定用于超声引导下神经阻滞对患儿围术期的影响","2023年度河北医学科技奖一等奖","1.沧州市中心医院2.南皮县人民医院3.河北省沧州中西医结合医院","1.姚忠岩2.张秀青3.娄宁4.汤国亮5.王玉","探索右美托咪定对于儿童的最佳用药剂量及方式，探讨右美托咪定对于儿童术后不良行为的改善","不同剂量右美托咪定混合罗哌卡因TAPB用于全麻腹腔镜手术患儿的效果","姚忠岩，瞿敏，杨强，汤国亮，刘问宾，于丽丽","中华麻醉学杂志","2019-08-01","艾司氯胺酮复合丙泊酚用于患儿纤维支气管镜检查术的效果","姚忠岩，娄宁，王玉，张秀青，刘旺，孙秀伟","中华麻醉学杂志","2022-11-01","超声引导喉上神经阻滞联合静脉麻醉用于纤维支气管镜诊疗术患儿的改良效果","姚忠岩，娄宁，齐曼曼，王玉，刘旺，孙秀伟，汤国亮","中华麻醉学杂志","2023-10-01"]
[45,"吗替麦考酚酯联合小剂量糖皮质激素治疗过敏性紫癜性肾炎的疗效研究","2023年度河北医学科技奖一等奖","123沧州市中心医院，4保定一中心","1张会武，2李秀丽，3徐海平，4冉方","采用吗替麦考酚酯联合小剂量激素治疗儿童过敏性紫癜肾炎","ffect and asfety enaluation of tacrolimus and tripterygium glycosides combined therapy in treatment of HEnoch-schonlein purpura nephritis","张会武，李秀丽，徐海平，冉方","International Journal of UrologyInternational","2021-05-30","The significance of the hemalexin C1q,RBP,and urinary NAG levels in the diagnoses and prognoses of children with purpura nephritis","张会武，李秀丽，徐海平","American journal of transational research",2021,"CdSe/ZnS quantum dots exhibited nephrotoxicity through mediating","张会武，李秀丽，徐海平","Aging-US",2020,"吗替麦考酚酯联合糖皮质激素对过敏性紫癜性肾炎患儿肾功能机免疫功能的影响","张会武，李秀丽，徐海平","中国病案","2019年6月\n"]
[46,"联合化疗对NSCLC患者血清相关炎性因子、CEA、TAP及免疫指标\n的影响\n","2023年度河北医学科技奖一等奖","沧州市中心医院","1.许金花2.李静静3.吴国峰4.张骞云5.王雪","研究化疗对非小细胞肺癌患者TNFα与相关炎性因子、肿瘤标志物、免疫指标的关系，并深入探讨它们之间的相关的作用机制为非小细胞肺癌的治疗提供新的线索和思路。","Pemetrexed Versus Docetaxel to Modulate Immune Environment in NSCLC Patients","许金花、李静静、吴国峰、张骞云、王雪、任亚俊","Journal of Biological Regulators & Homeostatic Agents","2023-02-10","Circular RNA hsa_circ_0068252 Functions in Cisplatin Resistance and Immune Response via miR-1304-5p/PD-L1 Axis in Non-Small Cell Lung Cancer","李静静、许金花、吴国峰、张骞云、王雪、任亚俊","Chemotherapy","2022-11-01"]
[47,"差异表达的长链非编码 RNA 在 Her2（+）胃癌中作用机制的研究","2023年度河北医学科技奖一等奖","沧州市中心医院","张吉水 吕文浩 高新 陈宝胜 崔秀霞 马秋桐\n刘雅刚 付蔚华","1.探讨了长链非编码RNA LINC_00355在胃癌进展中的作用，证实LINC_00355通过结合miR-15a-5p上调PHF19来促进胃癌发展。2.采用细胞试验探讨血清和糖皮质激素调节激酶1对胃癌进行顺铂治疗的影响，证实SGK1的下调通过抑制NF-κB信号通路抑制胃癌细胞的恶性行为，增强胃癌对顺铂的敏感性。并通过抑制NF-κB途径减轻胃癌的恶化。3.通过细胞试验探讨NUP37在胃癌中的作用，证实NUP37可能通过激活PI3K/AKT/mTOR信号通路，在胃癌细胞中发挥肿瘤激活剂的作用。","LINC_00355 promotes gastric cancer progression by upregulating PHF19 expression through sponging miR-15a-5p","张吉水 吕文浩 刘雅刚 付蔚华 陈宝胜 马秋桐 高新","BMC CANCER","2021-06-02","Knockdown of Serum- and Glucocorticoid-Regulated\nKinase 1 Enhances Cisplatin Sensitivity of Gastric Cancer Through Suppressing\nthe Nuclear Factor Kappa-B","张吉水 吕文浩 刘雅刚 付蔚华 陈宝胜 马秋桐 高新 崔秀霞","BALKAN MEDICAL JOURNAL",2021.11,"Nucleoporin 37 promotes the cell proliferation, migration, and invasion of gastric cancer through activating the PI3K/AKT/mTOR signaling pathway","张吉水 吕文浩 刘雅刚 付蔚华 陈宝胜 马秋桐 高新 崔秀霞","IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMA",2021.12]
[48,"《PCI术后患者无复流现象与Ⅱ型糖尿病相关性研究及机制探讨》","2023年度河北医学科技奖二等奖","1沧州市中心医院2沧州和平医院","黄瑞 赵素锐 李亚 刘芳 龚玥 邢军","完善 PCI 术后患者无复流现象与Ⅱ型糖尿病相关性的理论基\r础；\r指导临床此类患者的治疗；\r充分发挥理论优势进一步指导临床工作。","伴2型糖尿病的急性心肌梗死经皮冠脉介入治疗\n术中无复流的因素分析及建议探讨","龚玥 黄瑞 赵素锐  李亚 刘芳 邢军 ","临床急诊杂志","2019-12-10","\nSignaling Pathway","刘芳  黄瑞 赵素锐 李亚 龚玥 邢军","中国老年学杂志","2021-04-25","Association of tumor necrosis factor-α gene\r\npolymorphisms and coronary artery disease\r\nsusceptibility: a systematic review and\r\nmeta-analysis\r\n","黄瑞 赵素锐 李亚  刘芳 龚玥 邢军 徐泽升","SMC Medical Genetics","2020-02-11","Study on Correlation between Type 2 Diabetes and No-Reflow\r after PCI\r\n","赵素锐 黄瑞 李亚  刘芳 龚玥 邢军","Disease Markers","2022-03-17"]
[49,"miRNA 在神经系统退行性疾病中的意义","2023年度河北医学科技奖二等奖","沧州市中心医院 ","姚玉芳 张福波 徐鑫 苗娜 杨潮萍","本研究发现某些miRNA在帕金森病中异常表达，发现miRNA与帕金森病运动障碍及认知障碍相关。","microRNA-221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson’s disease","姚玉芳 赵治月 张福波 苗娜 徐鑫 杨潮萍","Brain And Behavior","2023-01-31","LncRNA MAGI2-AS3靶向调控miR-1277-5p对帕金森病细胞模型损伤的影响","徐鑫  姚玉芳 张福波 苗娜 王男 杨潮萍","遵义医科大学学报","2021-10-01","血清外泌体来源的miR-425-5p与帕金森病认知功能的相关分析","王男  姚玉芳 张福波 苗娜 徐鑫 杨潮萍","山东医药","2022-05-15"]
[50,"低张饮水MRCP结合薄层T2WI结合LAVA增强在低位胆道梗阻病变诊断中的应用","2023年度河北医学科技奖二等奖","1沧州市中心医院，2沧州市人民医院","1董红焕 2李佳玥 3杨琳 4康立清 5程思佳","本研究采用低张饮水MRCP及薄层T2WI结合LAVA增强的方法，，改善胆总管下段及十二指肠乳头区病变的图像质量，提高胆总管下段及十二指肠乳头区病变的检查率及诊断准确率","MRI在十二指肠乳头腺瘤诊断中的价值","董红焕,康立清,张荣菊,熊立新,孙敏,孙连营","临床放射学杂志","2019-01-20","MRI在胆管内乳头状黏液性肿瘤诊断及鉴别诊断中的价值","董红焕,康立清,程思佳","临床放射学杂志","2022-04-20","MRI在十二指肠乳头腺癌术前TNM分期中的价值","董红焕,康立清,杨琳,李佳玥,程思佳,郭靖,王振勇","医学影像学杂志","2023-02-28"]

{"sheet":"Sheet2","index":1,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}

{"sheet":"Sheet3","index":2,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}